Under the impact of hydrodynamic factors such as reservoir level fluctuations or rainfall, the slope in the reservoir area is prone to hydrodynamic landslides, thus threatening the life and property safety of residents in the reservoir area. Based on the geological investigations and remote sensing interpretations of the existing landslides in the research region, the spatial analysis of the ArcGIS was combined with the three-dimensional slope stability analysis model (Scoops 3D) to perform a systematic three-dimensional search and identification of potential landslides in the main study reservoir from the HD section to the DHQ section. The calculation parameters were determined based on the GIS data and laboratory tests. The regional landslide stability under natural and rainstorm conditions was evaluated and compared. The research results indicate that:(1) the distribution of historical landslides in the research region has a strong correlation with the geological conditions and the strength parameters of the rock and soil;(2) Under natural conditions, the unstable area is mainly distributed in DHQ section, Yichang, DH dam site, Labatie, Baota River and near Dianwei;(3) Under rainstorm conditions, the distribution range of unstable areas is significantly larger than that in the natural conditions, unstable areas are densely distributed near the DHQ dam site, Yingpan Town, Dianwei and HD dam site;(4) The distribution of unstable areas calculated by the model under the rainstorm conditions is basically consistent with the distribution characteristics of historical landslides. It can be seen that the three-dimensional slope stability analysis model can accurately simulate landslide stability under different working conditions, and the degree of susceptibility can be distinguished clearly. The calculation results reflect the spatiotemporal distribution of stability in the research region to a certain extent.