The interaction characteristics of cement paste with surrounding rock and lining segment in a subsea shield tunnel were studied by taking the subsea shield section of Xiamen Metro Line 2 as the engineering background. Numerical simulation and field measurement were carried out to analyze the solidification process of grouting slurry, focusing on the influence characteristics of compressive strength, stiffness, shrinkage and creep of cement paste on mechanical behavior and deformation of the tunnel, and the stress characteristics of the lining segment with different strata distribution and dif- ferent tunnel depths. Also, the influence of sea water level change on the stress of the lining segment was studied by the fluid-structure coupling technique. The calculation results show that the stiffness ra- tio E1/E28 of grouting material has less influence on the final axial force of the lining segment and the pressure of surrounding rock, producing a variation range of no more than 0.885%, while has a large influence on formation deformation. The setting time can be adjusted by additives to make the grout solidify and harden as early as possible; It is suggested that the grout with a low bleeding rate should be used, and its shrinkage value should be controlled in a small range; The creep parameters have lit- tle effect on the axial force,with a maximum variation range of less than 1.35; The shrinkage parame- ter mainly considers the solidification shrinkage of grouting material in the later stage, while creep pa- rameter mainly considers the creep shrinkage of grouting material in the earlier stage; If the soft soil is thick, the effective pressure arch is not easy to form, which leads to a large surrounding rock pres- sure; The semidiurnal tide has little effect on stratum deformation and segment stress, and the general development trend is similar to that under the static water level. Finally, the monitoring results show that the numerical simulated time history variation law of soil and water pressure in the segment is ba- sically consistent with the measured one.