In view of the simulation problem caused by large displacement problems such as soil slid- ing, the influence of landslide disaster on the operation of aviation fuel pipeline laid across the slope is analyzed. Using the SPH-FEM coupling algorithm and adopting different contact models to establish the full-size coupling models of pipe-soil interaction and pile-soil interaction, the nonlinear analysis is carried out to obtain the law of mechanical response of pipeline-soil, and the anti-slide performance of slide-resistant piles is analyzed to ensure the safety of the pipeline body in the landslide area. The re- sults show that, under the working condition of this paper, when the landslide tends to be stable, the maximum values of displacement and stress developed in the pipeline under the action of soil thrust ap- pear in the landslide body. However, due to the “soil arching effect” between the pile and the soil, the sliding soil behind the pile is more likely to stabilize, and the pipeline does not twist along the tube ax- is. With the increase of the number of slide-resistant piles, the anti-slide performance increases. How- ever, for the working condition in this paper, the anti-slide scheme comprising two anti-slide piles with concrete strength of C30 can ensure the safe operation of the pipeline. The conclusions can pro- vide theoretical support for the safe operation of aviation fuel pipeline, and present a feasible simula- tion method for the study of the mechanical behavior of pipelines under landslide and the anti-slide per- formance of slide-resistant piles.