The southeast region of Tibet is the largest marine glacier area in China. For investigating the physical and mechanical characteristics of glacial tills along the Sichuan-Tibet railway， and evaluating their stability as a geological hazard source and engineering foundation， 32 points of glacial tills in the Parlung Zangbo basin were taken as cases. A series of in-site and indoor tests on natural density， grain size analysis， large direct shear， triaxial shear， compressive strength， permeability coefficient and so on were carried out. Combining with field investigation methods such as sectional surveying and mapping， the distribution， morphological characteristics， physical and mechanical properties of glacial till and their correlation were analyzed. The result shows that physical and mechanical properties are closely related to moisture content， void ratio and clay content. The natural density and compression modulus are negatively linear related to the void ratio. The vertical permeability coefficient and the free expansion ratio show a quadratic relationship with clay content. The shear strength and compressive strength are binary relationship with void ratio and moisture content. Start-up patterns in three different deposit sites (modern glacier tongue， middle reaches of the valley， and the main river bank) were summarized， and the stability of the glacial tills was preliminarily discussed. The countermeasures for dealing with the glacial tills in Sichuan-Tibet railway and highway projects were suggested， such as passing by bridges or tunnels， engineering slope， and cutting or foundation， etc.